What is Clomed?
As per the data given by Center for Disease Control and Prevention (CDC), there are 6.7 million women in US, aged between 15-44 sufferings from impaired fecundity. Impaired fecundity is an impaired ability to get pregnant or carry a baby to term. Out of these nearly about 1.5 million married women are unable to become pregnant after at least 12 consecutive months of unprotected sex with partner. One of the major causes for this is anovulation. Anovulation is a condition of absent ovulation or lack of ovulation in women or in other words when the ovary does not release a ripened egg during menstrual cycle every month.
To achieve a pregnancy, release of egg from the ovary must happen during a woman’s reproductive years. Generic Clomiphene citrate or its brand Clomid is the front runner in the treatment of normally oestrogenized, anovulatory women. When a woman, suffering with anovulation, takes Clomid or generic Clomiphene citrate, this medicine reduces the estrogen receptors at hypothalamus, this result in stimulating pituitary to release follicle stimulating hormons (FSH) much in the same manner as Gonadotropin releasing Harmon (GnRH) does. Many medical reports suggest that 50% patients ovulated after taking Clomid, and 30 % are enjoying the pleasure of parenthood. Before any women buy clomid for the treatment of infertility caused due to anovulation, she must note that weight reduction is an important part of this therapy, as body mass index is very closely associated with negative response to Clomid.
One must avoid any other ovulation induction therapy along with Clomid as; this may result into multiple follicular developments, increasing the chances of ovarian hyperstimulation and multiple pregnancies.
How Clomed Works
An orally administrated medicine for treatment of infertility in women, Clomid (Clomiphene citrate USP tablet) is a non-sterodial, ovalatry stimulant. This medicine has a great success rate of treating women with infertility caused due to anovulation is designated pharmacologically as 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). This medicine has a chemical formula of C26H28ClNO • C6H8O7 and 598.09 amu molecular weight. Generic Clomiphene can get easily soluble in methanol and in ethanol, where as partially soluble in acetone, chloroform and water, is white to pale yellow in color. This medicine is odorless.
Branded as Clomid, generic Clomiphene is a combination of two geometric isomers. Each tablet of Clomid contains Clomiphene 50mg as active molecule and corn starch, lactose, magnesium stearate, pre-gelatinized cornctarch and sucrose as in-active compounds.
With proper care and dose management, Clomid, a pharmacologic potential medicine has shown high rates of success while treating anovulatory patients desiring pregnancy. When a patient starts a dose of clomid 50mg, the active compound Clomiphene starts a series of endocrine event with tissues containing estrogen receptor culminating in a pre-ovulatory gonadotropin resulting in succeeding follicular rupture. As the endocrine series starts release of pituitary gonadotropins increases, which further initiates steroidogenesis and folliculogenesis. This whole process results in growth of the ovarian follicle and increasing and decreasing level of estradiol and pro-gesterone same as it happens in a normal ovulatory cycle.
The two geometric isomers of Clomiphene citrate, cis zuclomiphene and trans enclomiphene has estrogenic and anti-estrogenic properties. Pretreatment evaluation: - Clomid acts on the hypothalamus, pituitary gland and ovary to increase FSH levels and thus completing the infertility therapy in women suffering from absent ovulation, very low level of estrogen, or high level of FSH or with polycystic ovary syndrome.
How to start the dose of Clomed
It is very important to know how to start and when to start the dose of Clomid for successful treatment of infertility. To get the best result from clomid, it is advised to start the your dose of Clomiphene 50mg on third, fourth or fifth day of your menstrual cycle, taking one pill of 50mg every 24 hours for five day. To calculate the day’s one can take first day of menstrual bleeding as day one. Some healthcare providers recommend single course of progestin medicine like Provera to push a menstrual cycle, if the women does not have regular period. But recent developments in the treatment of infertility with clomid suggest that the pregnancy rate is higher without inducing bleeding with medroxyprogesterone like Provera.
During a cycle of 28 days, the ovulation occurs between 14 to 19 days of the cycle. To optimize the chances of getting pregnant with clomid, one must use ovulation predictor kit (OPK) to plan intercourse. The ovulation predictor kit uses the urine sample to predict ovulation by measuring the luteinizing hormone level. The first day of luteinizing hormone surge between midnight to 8 am and the following day are the best time to plan intercourse. This means, checking the ovulation in the morning hour using OPK may miss day one of LH surge. This is advisable to check the OPK in the afternoon might be better to onset the LH surge.
If someone does not want to use the OPK kit, it is advised to have intercourse every alternate day for one week on around tenth day after the menstrual period starts. This may need survival of the sperm in the upper genital tract which may dim the chance in some instances.
After completing the first month of treatment with clomid, if the ovulation does occur and pregnancy is not gained, it is advised to increase the dose of Clomid 50mg each month until ovulation occurs. If the pregnancy does not occur after ovulation, there is no benefit of increasing the dose as there may be some other reason for failure to achieve pregnancy. There are chances that the failure to attend pregnancy is due to man’s infertility. Studies show that pregnancy is achieved within the first six ovulatory cycles when Clomid is used for infertility treatment.
Benefits — The first and the for most benefit of cusing clomid as the infertility therapy is the it is very low costing in comparision to the other therapy available for the same such as hysterosalpingogram or laparoscopy, gonadotropin therapy, in vitro fertilization. Treatment with Clomid does not require ultrasound or blood harmon monitoring. The risks of severe side effect are very low with generic Clomiphene which improves the chances of becoming pregnant in number of women who suffer from no ovulation or irregular ovulation.
Risks — Risk of Clomid therapy includes multiple pregnancies, enlarged ovaries.
Common side effects: Common side effects of Clomid are stated below:
- Hot Flashes
- Abdominal Bloating and pain
- Mood Change
- Breast Tenderness
- Visula Symptoms like, blurring, double vision
How to Improve Clomid Success: If a woman does not conceive after the cycle of clomid are advised for an X-ray to know as Hysterosalpingogram showing the uterus and fallopian tubes, few blood test and a semen count test of the male partner.
Weight Loss: Body Mass Index (BMI) is carried out for women who are overweight or obese. As per the body mass index (BMI) if a women has weight greater weight than 25 kg/m Squire.
If these tests are normal and the couple would like to continue with clomiphene treatment, other investigations, such as weight loss or gain, might be suggested. A normal or near normal weight according to BMI reduce the risk of complications during pregnancy and delivery. Weight gain: - Being under weight also acts as a hindrance in initiating an ovulation, according to body mass index. If the weight is less than 17 kg/m square may increase complication in achieving ovulation.